Molecular modeling of lipid drug formulations

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Molecular modeling of lipid drug formulations

Lipid formulations can improve the bioavailability of drugs that have low aqueous solubility. A variety of chemical compounds, including triglyceride oils (lipids), fatty acid esters and surfactants, can be included in lipid formulations. This heterogeneity makes spectroscopic study of the in ternal structure of formulation difficult. Understanding of lipid formulations at a molecular level wil...

متن کامل

Drug Dosage Formulations

The discovery and development of a new drug can be a lengthy and expensive business (Fig. 1). The starting point is the active compound as synthesized by the medicinal chemist and screened by the pharmacologist. There then follows a series of complex tests and evaluations to produce a satisfactory formulation and sufficient data for presentation to regulatory authorities such as the Committee o...

متن کامل

Large Scale Molecular Dynamics Simulations of Lipid-Drug Interactions

Molecular dynamics is a powerful computational technique for studying biochemical systems at the atomic resolution. We will present the results of several recent studies in our laboratory that apply molecular dynamics to the distribution and behaviour of small molecules within lipid bilayer environments similar to the membrane surrounding all cells. Specifically, we have studied the distributio...

متن کامل

Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Lipid Based Formulations - A Review

More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is...

متن کامل

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Identification of the usefulness of lipid-based formulations (LBFs) for delivery of poorly water-soluble drugs is at date mainly experimentally based. In this work we used a diverse drug data set, and more than 2,000 solubility measurements to develop experimental and computational tools to predict the loading capacity of LBFs. Computational models were developed to enable in silico prediction ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Cheminformatics

سال: 2012

ISSN: 1758-2946

DOI: 10.1186/1758-2946-4-s1-o23